Resident Evil Requiem: How to Unlock Every Safe – Trophy Guide

Why You Should Clear Every Safe on Your First Run

After spending a good chunk of my first Resident Evil Requiem playthrough wandering around Roads Hill wondering what safe I’d missed, I finally sat down and routed every single one. The breakthrough came when I realized two things:

1) The codes are actually written in files you can easily walk past, and those files also count toward the “read every file” trophy.
2) On Insanity mode, the combinations change, so it’s way easier to grab all the codes and safes properly on a standard run first.

This guide walks you through every safe (plus the STARS briefcase) in order of appearance, gives you the exact combinations, where to find the file that reveals each one, and what you’ll get for cracking them. I’ll also flag the spots where I almost locked myself out of the all-safes trophy, so you don’t repeat my mistakes.

Quick Reference – Every Safe & Briefcase Code

If you just want the combinations, here’s the full list. Direction means which way to rotate the dial. Think of it like classic Resident Evil safes: stop exactly on the number before switching directions.

• Roads Hill – Bar & Lounge Safe (West Wing 2F)
  Code: Left 10, Right 80, Left 30
  Reward: 3× Antique Coin
• Roads Hill – Examination Room Safe (East Wing)
  Code: Right 30, Left 10, Right 50
  Reward: 3× Antique Coin
• Roads Hill – Basement Office Safe
  Code: Right 60, Left 40, Right 80
  Reward: Mr. Raccoon Roads Hill map
• RPD – STARS Briefcase (letter lock) – does not count as a “safe” for the trophy, but the file does count for the file trophy
  Code: R R R
  Reward: Power Shades charm (piercing & buffed handgun shots)
• Ark – Sterilization Chamber Safe (4F East)
  Code: Right 10, Left 90, Right 20
  Reward: Handgun ammo, Molotov cocktail, Med Injector
• Ark – Control Monitor Room Safe (Lobby side room)
  Code: Left 50, Right 60, Left 80
  Reward: Empty bottle, Bottle of acid, Med Injector

The five numbered containers are what you need for the “open all safes” trophy. The STARS briefcase is optional for that trophy, but grabbing it while you’re there will save you a lot of backtracking later.

Roads Hill Safes – Bar, Exam Room, and Basement

1. Bar & Lounge Safe (West Wing 2F)

This is probably the first safe you’ll see, and it’s exactly where I started overthinking things.

Where the safe is:
In the Bar & Lounge on the 2nd floor of Roads Hill’s West Wing. The safe is sitting right on the bar counter.

The catch is that this room has a wandering singing zombie plus two regular infected. You can technically sneak the safe without killing them, but I learned the hard way that coming back here later with worse spawns is even more annoying.

Enemy tip: If you do decide to clear the room, use a Hemolytic Injector on the singer if you can spare it. Otherwise those enemies have a good chance of coming back later as Blister Heads, and that gets nasty fast.

Where the code file is:
Keep playing through the West Wing 2F until you reach the south‑western office (a small office beyond a set of double doors). On the desk directly opposite the doors is a note with the safe combo. This file also counts toward the all‑files trophy, so make sure you actually read it (interact and bring it up on screen).

Combination & reward:
Dial in Left 10, Right 80, Left 30 to open the bar safe and you’ll get 3× Antique Coin.

What finally worked for me: I now grab the code file as soon as I hit that office, then immediately double back to the bar before progressing the story in that wing. It adds maybe two minutes of walking but keeps everything in one clean loop.

2. Examination Room Safe (East Wing)

This one is easy to see but even easier to forget, because the game distracts you with a big set‑piece right before you find the file that reveals the code.

Where the safe is:
In the Examination Room in Roads Hill’s East Wing, sitting on a counter near the corpse missing its organs. You’ll pass this room naturally as you explore the wing.

Where the code file is (Chunk ambush area):

• Head up to the 2nd floor of the East Wing, following the story progress toward the Level 1 security bracelet.
• As you approach the bracelet in the hallway, you’ll be ambushed by a heavy enemy nicknamed Chunk.
• Focus on survival here; don’t worry about any collectibles during the chase.
• Once you’ve escaped and things calm down, return to that same hallway and take the right‑hand path at the end.
• In the bloody dead end is a table with a file on it – this is your safe combination document.

You’ll see the code written as: Right 30, Left 10, Right 50.

Combination & reward:
Back at the Examination Room, spin the dial Right 30, Left 10, Right 50. Inside are another 3× Antique Coin.

Time‑saving tip: Don’t make my mistake of grabbing the file, saving, and assuming you’ll remember to come back later. The best time to open this safe is immediately after the Chunk encounter while the route through the wing is still fresh and relatively safe.

3. Basement Office Safe (Roads Hill)

This is the one that cost me my first all‑safes trophy. The code is obtained with one character, but the safe itself can only be opened later with another. Miss the code file and you’re in for an annoying replay.

How the sequence works:

• You eventually drop into the Roads Hill basement as Grace.
• After that sequence, control shifts back to Leon in the attic, where he has to fight another Chunk.
• Right after this fight is the window where you can grab the code file.

Where the code file is (Leon in the attic):
After beating Chunk with Leon, continue down the hallway. On the right, by the stairs, there’s a closet with a warped door. Leon can pry these open using his hatchet (interact when the prompt appears).

Inside the closet is the file with the safe combination: Right 60, Left 40, Right 80. Read it so it counts for the file trophy.

Where the safe is (Grace in the basement):
Once you’re back in control of Grace in the basement, explore the north‑western room. There’s a small office near a powered‑down forklift; the safe is in that office.

Combination & reward:
Enter Right 60, Left 40, Right 80. This safe doesn’t give coins – instead you get a map showing all Mr. Raccoon statues in Roads Hill. If you’re trophy‑hunting those collectibles, this map is huge.

Critical warning: Do not leave the basement area before opening this safe. Progressing the story can make it much harder or even impossible to return depending on your route. I always open it the moment I find the forklift room, before touching any other objectives.

RPD STARS Briefcase – Power Shades Charm

The next container isn’t technically a “safe” for the trophy, but it’s absolutely worth doing. It’s also one of the more classic Resident Evil puzzle chains in Requiem, full of references.

Where the briefcase is:
When Leon returns to the Raccoon Police Department, head to the STARS office on the 2nd floor (west side). In the small storage room at the back of the office is a locked briefcase with a three‑letter dial.

You can’t brute force this easily; instead, you follow a little breadcrumb trail of files and photos.

Step‑by‑Step File Trail

• 1. Barry’s locker photo: In the main STARS office, open the locker to find a photo and a message from Barry Burton, hinting that the briefcase combo is tied to a colleague.
• 2. Wesker’s desk note: Go into Wesker’s private office (separate from the shared desks). Open the drawer at his desk and wait a moment; a hidden note drops down. Read it – it mentions a particular book Wesker checked out.
• 3. Library book: Head to the 2F library on the same floor. Go up to the upper level and cross to the sealed door. On the right‑hand shelf there’s now an interactable book (this only becomes readable after you’ve seen Wesker’s note). Inside is a photo of Rebecca Chambers. Flip it over to read the phrase “rising rookie Rebecca”.

All three words begin with R. That’s your clue.

Combination & reward:
Back at the briefcase, set the letters to R R R. Inside you’ll find the Power Shades charm, a stylish little reference that also gives your handgun bullets piercing properties and boosts the damage of the last round in the magazine.

Why I recommend this even though it’s optional: The damage bump and piercing effect make crowd control way safer in tight corridors, especially on higher difficulties. It doesn’t count toward the all‑safes trophy, but the associated files help with the file trophy, and the charm is strong enough that it’s worth the few extra minutes of sleuthing.

Ark Lab Safes – Sterilization Chamber & Control Monitor Room

The final stretch of safes is in the Ark, when you’re exploring as Grace. Both codes are hidden in the same nasty area, so you can grab them in one pass and then open both safes almost back‑to‑back.

4. Sterilization Chamber Safe (4F East)

Where the safe is:
From the Ark lobby typewriter, head up to the 4th floor east. The Sterilization Chamber is just up the stairs on that side. The safe sits on a counter inside the room.

Where the code file is (Bioweapon Repository 5):

• Before that, on the 3rd floor, you’ll reach Bioweapon Repository 5, a room packed with containment pods and some very aggressive Lickers.
• From the stairs, instead of going straight into the main room, turn right and check a nearby storage pod.
• Inside is a file with the safe code.

The combination is written as Right 10, Left 90, Right 20.

Combination & reward:
In the Sterilization Chamber, enter Right 10, Left 90, Right 20. You’ll get a nice survival bundle: handgun ammo, a Molotov cocktail, and a Med Injector.

Lickers survival tip: On my first run I tried to sprint through Repository 5 and kept getting chain‑stunned. It’s much safer to lure one Licker at a time toward the door, use tight corners to break line of sight, and only then duck into the side pod to grab the file when things are quiet.

5. Control Monitor Room Safe (Lobby Side Room)

This is the last safe you need for the trophy, and conveniently its code is also in Bioweapon Repository 5.

Where the code file is (same repository, different pod):

• Still in Bioweapon Repository 5, look along the eastern wall.
• There’s another storage pod roughly midway up the wall that you can open.
• Inside is a second file with the combination: Left 50, Right 60, Left 80.

Where the safe is:
Return to the Ark lobby. The Control Monitor Room is a small side room just off the lobby, with obvious banks of screens. The safe is hard to miss once you’re inside.

Combination & reward:
Dial Left 50, Right 60, Left 80 to open it. You’ll receive an empty bottle, a bottle of acid (for crafting stronger throwables), and another Med Injector.

Trophy note: Assuming you’ve opened the three Roads Hill safes and the Sterilization Chamber safe before this, popping this final one should trigger the all‑safes trophy immediately.

Trophy & Insanity Mode Tips

From my runs and what I’ve seen in the community, here’s how I’d handle safes if you’re planning on going for the platinum:

• Read every code file even if you already know the combo. The “read all files” trophy is strict – you need to actually open each document at least once. Don’t just rely on memory from a guide.
• Clear each safe as soon as you reasonably can. Roads Hill in particular loves to lock off or repopulate areas. Doing each safe while you’re already in that wing prevents painful backtracking.
• Treat the Basement code file as mandatory before leaving the attic Chunk fight area. That’s the easiest one to miss and will quietly break both the safe trophy and file trophy if you forget it.
• On Insanity difficulty, expect different codes. On my runs, the base‑game difficulties shared fixed combinations, but Insanity shuffled them. Always reread the in‑game file on that mode instead of punching in your old notes.

Once you’ve followed this route, you’ll have:

• All five numbered safes opened (trophy unlocked)
• The STARS briefcase solved and Power Shades charm equipped
• A big stack of Antique Coins for upgrades
• The Roads Hill Mr. Raccoon map to clean up collectibles
• Progress toward (or completion of) the all‑files trophy

If you stick to opening each safe as you pass through its area, you can grab everything in a single standard playthrough without ever needing to reload an old save. I had to learn that the hard way; you don’t have to.