Short answer: the Chunk you meet as Grace in the Rhodes Hill Care Center East Wing (2F) is an optional kill, and the clean way to do it is three Hemolytic Injector backstabs on Standard. Craft your injectors first, learn his ground-floor patrol, and stab-and-retreat from a safe room between each one. The payoff is the Eye Spy charm — which raises Grace’s chance to survive a fatal hit — and the “Grace and Goliath” trophy/achievement. None of this has been changed by a patch; the current build is 1.3.1 (25 June 2026).
Below: the spawn trigger, exactly what to craft, his patrol, the safe rooms he will not enter, and the two mistakes that ate most of my failed attempts.
You meet him as Grace, in Resident Evil Requiem’s Rhodes Hill Care Center, on the 2F East Wing — the same wing that holds the Level 1 ID Wristband. The trigger is story progress: you explore toward the Lead Researcher’s Office, solve the combination puzzle on the cabinet there, and collect the key items. That is when he makes his entrance.
Important framing: this Chunk is a separate encounter from the Chunk that Leon fights later in the attic. You are allowed to simply avoid this one. Killing it is worth doing anyway, and this guide assumes you want to.
Survive the initial chase first. You are not expected to kill him during it:
Requiem is on 1.3.1, released 25 June 2026. Across every post-launch update — the 1.1.0 day-one patch, the 4 March PC progression fix, the 9 March Switch 2 fix and 1.3.1 — nothing in the published notes touches Chunk’s health, hitboxes, detection or the injector count. Guides updated through mid-2026 still list the same three-injector kill, the same Eye Spy drop and the same trophy. Balance chatter in the community has centred on other encounters and on Insanity tuning, not on this one.
Three successful backstab injections kill him on Standard. That is the number every major guide lands on, and no source reports a higher requirement on harder difficulties — though on Insanity you should assume less margin for a botched approach, not a different count.
The recipe unlocks after you solve the Requiem blood analyzer puzzle in Grace’s section. Each injector consumes one Hemolytic Vial and one Requiem Sample, so budget three of each before you commit. Sit in a safe room, open the crafting menu, and confirm you can build at least two before you start poking a giant meat wall — running out mid-sequence means backtracking to farm while he is still patrolling.
Grace can fire Requiem bullets from the weapon Leon gives her. They are powerful and scarce — you craft more from rare materials, and you will never be swimming in them. On my run, two injectors plus one clean Requiem headshot produced the same collapse-and-bleed-out death as three injectors, on Standard.
Treat that as a fallback, not a plan. A missed headshot is far more expensive than a botched injector approach, because injector materials are replaceable and Requiem rounds effectively are not. I have not tested the 2+1 route on Insanity, so do not assume it holds there.
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Once the initial chase resolves, Chunk settles into a loop on the East Wing ground floor. Watching him over several attempts, the route runs between the Examination Room, the Waiting Room and the corridor toward the Blood Lab. He lumbers up and down that main hallway and will sometimes turn around halfway, which is the single most dangerous thing about him.
The reason this encounter is winnable with almost no ammo is that some rooms are hard boundaries he will not cross:
The whole fight is dancing between those two doors and the corridor between them. Wait for his back, slip out, stab, retreat.

You want him walking past the door with his back turned, heading toward the Examination Room end.
He reacts violently, but you get a window. As soon as the animation ends, sprint into the Waiting Room or the Examination Room, whichever is closer, and shut the door. He will stomp around outside and give up.
Wait him out, then repeat from whichever safe room you are in — watch him head toward the Blood Lab side, follow at distance, circle behind, stab. After this one he visibly destabilises: jerkier movement, more blood. He is still lethal if he corners you. Retreat immediately, same as before.
This is where impatience ends runs. Give him time to fully reset his patrol; do not leave the room the second the stomping stops, count a few extra seconds. Then run the same approach.
When the third injector lands, Chunk crumples and starts spewing blood — the hemolysis is finishing him. Back off and give him space; there is nothing left to do. Once he collapses, walk into the remains and pick up the Eye Spy charm.

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If an approach goes wrong and he spots you, sprint to the nearest safe room and reset. Do not try to salvage it with desperation shots in the open.
No. This encounter is optional — you can bypass him entirely. You would be giving up the Eye Spy charm and the trophy.
Three backstab injections on Standard. No source reports a different count on higher difficulties.
No. Leon faces a separate Chunk later, in the attic, as a mandatory fight. Our full boss guide covers that version.
No. Through the current 1.3.1 build (25 June 2026), nothing in the published notes alters Chunk’s health, weak points or behaviour.
Do it once and it stops reading as a horror set piece and starts reading as a puzzle: respect the patrol, use the doors, let the injectors do the work. If you are still short on materials, our early-game ammo conservation notes will get you there faster.