All 50 Challenges in Resident Evil Requiem (Full Guide & CP Rewards)

Why Challenges Matter (and How I Approached Them)

After spending about 15 hours chasing Challenges in Resident Evil Requiem, I realized they’re basically the spine of the game’s endgame: they feed you CP for infinite ammo, bonus weapons, models, concept art, charms, and costumes. There are exactly 50 Challenges total, and many overlap with trophies/achievements, so planning your runs around them saves a ton of time.

The breakthrough for me came when I stopped treating Challenges as “extras” and started routing my whole playthrough around them. This guide runs through every documented Challenge, explains which ones are story-locked, and gives practical tips from my own attempts-especially for anything involving the Blood Collector, hemolytic injector, or Requiem weapon.

How Challenges & CP Work in Resident Evil Requiem

Challenges are special objectives that track across your saves. You can view them from the main menu or the pause menu in the Challenges tab. When you complete one, you’ll see a notification when loading or pausing, and it gets a red checkmark in the list.

Each completed Challenge awards CP (Challenge Points). You spend CP in the Bonuses menu to unlock:

• Character and enemy models
• Concept art galleries
• Weapons and weapon variants
• Charms and costumes
• Powerful extras like infinite ammo and unbreakable melee weapons

For example, infinite ammo for all guns costs a massive chunk of CP, and the RPG-7 plus its infinite-ammo variant together eat a big portion of your total earnings. That means CP-efficient Challenge routing is the fastest way to fully kit out your save.

Important structural note: there’s no chapter select and no free-roam after the ending. Once you move past key transitions (like the Care Center basement elevator), you can’t go back. I used almost every one of the 12 manual save slots as “backups” just before points of no return so I could mop up missed Mr. Raccoons, safes, or BSAA containers.

Story & Difficulty Challenges

These are mostly automatic if you finish the game on different settings, but there are tricks to doing them efficiently.

• It’s Been a Long Night – Reach the Care Center courtyard.
  This is story-locked during Grace’s opening sequence. Just keep following the main objectives until you exit into the courtyard; you can’t miss it.
• Hope and Requiem – Release Elpis and complete the story.
  This is your “normal” ending clear. Once you’ve released Elpis at the end of the campaign you’ll see this Challenge pop on the results screen. You have to finish the game at least once to unlock Insanity difficulty anyway, so think of this as your foundation run.
• Rookie Agent – Complete the main story on at least Casual difficulty.
  If you start on Casual, this unlocks by just beating the game. If you’re comfortable, skip straight to a higher setting so you don’t need a pure Casual run later.
• Rising Agent – Complete the main story on at least Standard (Modern).
  Starting a new game on Standard (Modern) will unlock both Rookie Agent and Rising Agent when you finish, so you don’t need to do Casual separately.
• Resolute Agent – Complete the main story on at least Standard (Classic).
  Standard (Classic) adds ink ribbons. If you clear on this mode, you’ll pop Rookie Agent, Rising Agent, and Resolute Agent all together. I did my first serious completion on Classic to knock out all three in one go.
• Remarkable Agent – Complete the main story on Insanity difficulty.
  Insanity unlocks after a Standard-complete run. Do this in New Game+ with upgraded weapons or, ideally, after you’ve bought at least one infinite-ammo unlock with CP. I wouldn’t attempt Insanity fresh; even basic encounters get brutal.
• Speed Demon – Complete the main story by releasing Elpis within four hours.
  This is your speedrun Challenge. I treated this as a separate NG+ Casual run:
  • Skip every cutscene.
  • Ignore almost all side rooms and non-essential combat.
  • Use upgraded weapons (or infinite ammo) to delete bosses.

  Even with a couple of mistakes, I finished in about 3 hours 20 minutes following the main path.

• Never Touch the Stuff – Complete the main story without using herbs or med injectors.
  This means no healing items, period. Auto-heal on yellow is fine; just don’t consume any healing objects. Do this on Casual and learn safe spots to run away instead of fighting. Personally, I combined this with a CP-rich NG+ run where I already knew enemy placements.
• Minimalist – Complete the main story as Grace without using the Blood Collector.
  The trick is simply never pick up the Blood Collector in the Care Center Blood Lab. Once it’s in your inventory, the run is invalid. I saved this for a later Casual run because it locks you out of other Blood Collector Challenges like Science! and Bloodlust on that file.
• The Final Puzzle – Let the sweet pair hear the voice.
  At the time I first cleared every other Challenge, this one was still effectively “TBD” in community guides. Treat it as a late-game secret related to audio or a specific duo encounter. I’d recommend finishing all other Challenges first so you can experiment freely here without worrying about missing anything else.

Together, these form the backbone of your multiple playthroughs: one thorough story clear, one or two higher-difficulty clears, and a dedicated speedrun / no-heal / minimalist setup if you want to combine them.

Grace’s Challenges: Blood Collector, Crafting & Early Survival

Grace’s section in the Care Center hides several of the most confusing Challenges, especially around the Blood Collector. I wasted a couple of hours before I understood how these worked.

• Out of Sight, Out of Mind – Store an item in the item box as Grace.
  The easiest possible Challenge: as soon as you reach an item box, put any item inside (even a single herb) and you’re done.
• The Ol’ Fashioned Way – Use an ink ribbon to save.
  Only available on Standard (Classic). Pick up an ink ribbon, interact with a typewriter, and confirm the save. Don’t overthink this-do it once early in a Classic run and you never have to worry about it again.
• Like Mother, Like Daughter – Unlock a drawer with a lockpick.
  Lockpicks are scattered around the Care Center. Once you find one as Grace, use it on any locked drawer (look for the little padlock icon). I recommend doing it as soon as you get your first lockpick so you don’t forget.
• Fatal Dose – Defeat a zombie using the hemolytic injector.
  You can first pick up the hemolytic injector in the Care Center Examination Room. A scripted infected doctor is the perfect test subject. Equip the injector, walk up, and use it-it’s an instant kill and completes the Challenge.
• Science! – Unlock a crafting recipe using analysis.
  In the Care Center Blood Lab, pick up the Blood Collector, then grab the Denatured Blood Specimen next to the Analyzer. Place both in the machine and complete the analysis puzzle. Doing this unlocks new crafting recipes and pops the Challenge.
• The Power of Blood – Craft an item using the Blood Collector.
  Once you’ve got the Collector, use it on one of the many blood buckets throughout the Care Center to gather microsamples. Then open the crafting menu and create any item that uses those samples.
• Blood! More Blood! – Use 300 microsamples of infected blood.
  This tracks the amount spent on crafting, not just collected. Craft ammo and injectors regularly instead of hoarding microsamples. I made a point of topping off my ammo with blood-based recipes whenever I passed a bucket; by mid-game, this Challenge was done.
• Bloodlust – Collect 5,000 microsamples of infected blood using the Blood Collector.
  This one’s a grind unless you abuse Transfusion Bags. Each bag can be “cashed in” for a big chunk of microsamples, and the game counts them even if you reload:
  • Use a Transfusion Bag to convert it into microsamples.
  • Let the Challenge counter tick up.
  • Reload a manual save from before using the bag and repeat.

  It’s a bit cheesy, but it works and saves a lot of backtracking.

Pro tip: Do all of these on a Grace-focused run where you do pick up and abuse the Blood Collector. Then do Minimalist on a separate file.

Leon’s Combat & Requiem Weapon Challenges

Leon’s sections in Wrenwood, Raccoon City, and ARK are where most combat-focused Challenges live. This is also where I farmed CP for big-ticket bonuses.

• The Hunt Begins – Destroy one Mr. Raccoon memoriam.
  Your first Raccoon can be shot in the room after the Rehabilitation Ward in Rhodes Hill Care Center, sitting on a shelf above a fireplace. Do this early so you understand what they look and sound like.
• Untouchable – Parry an enemy attack.
  With Leon’s hatchet equipped, wait for a zombie’s swing, then press the parry button just before impact. I practiced this during the initial Wrenwood outbreak until the timing felt natural.
• Can I Borrow This? – Throw a weapon dropped by an enemy.
  In the same Wrenwood streets sequence, grab a pipe or melee weapon a zombie drops, then immediately throw it at another nearby enemy. No need to kill—just land the hit.
• Chop Chop – Defeat three zombies with a hatchet finishing attack.
  Weaken zombies with gunfire; when the melee prompt appears, use the hatchet finisher. You don’t need a triple kill; just three separate finishing blows over the course of the game.
• Retail Therapy – Purchase an item from the supply box.
  In Leon’s Raccoon City section, you’ll reach the Central Camp with the Supply Box. Spend Credits on anything—ammo, health, whatever you need—and the Challenge unlocks.
• Tailor Made – Upgrade a weapon.
  At the same Supply Box, tab over to weapon upgrades and invest Credits into power, reload, or capacity for any gun. I upgraded my handgun first to stretch early ammo supplies.
• Road Rage – Stop one of Victor’s attacks on the highway.
  During the motorcycle chase, wait for Victor to line up beside you. A red arrow will appear over his head; shoot him quickly to interrupt his attack and complete the Challenge. Don’t panic—this window is more generous than it looks.
• Master Craftsman – Craft every possible item with Leon.
  Leon can learn nine recipes total. I kept a small pool of gunpowder and parts in reserve and, once I’d unlocked all recipes, sat at a safe room and crafted one of each, even if I didn’t need them immediately.
• Bang For Your Buck – Defeat at least three enemies with a single Requiem shot.
  Your best shot is in Wrenwood when you first get the Requiem weapon. Kite a pack of zombies into a straight line in a street or hallway, then fire through their torsos. Aim low to hit legs and guarantee knockdowns.
• Cat Got Your Tongue? – Cut the tongue off a Licker using the hatchet.
  In ARK, when a Licker lashes out with its tongue, parry the attack with the hatchet. Time it like any other parry; if you succeed, you’ll sever the tongue and instantly unlock this Challenge.

These Challenges are also great practice for higher difficulties. Getting confident with parries and Requiem positioning made my Insanity run substantially less painful.

Boss & Encounter-Specific Challenges

• Bring Out the Big Guns – Stun the Girl with Requiem.
  During the encounter with “The Girl” at the Water Treatment Plant, you’re given the Requiem. Wait for her to commit to a rush attack, then hit her center mass. If you connect while she’s mid-charge, the stun is guaranteed.
• Order Up! – Defeat the chef in the Care Center.
  This hulking enemy patrols the West Wing Kitchen area. I lured him into a doorway so he had trouble getting around tables, then repeatedly staggered him with handgun headshots. Loot the body for the Pantry Key and the Stakeout Takeout charm.
• Deadly Duet – Defeat the two singers.
  These siren-like zombies appear in the Bar Lounge and Conference Room of the Care Center. I prioritized them the moment I heard the singing; if you leave them alive, they can cause chaos by aggroing nearby enemies.
• Grace and Goliath – Defeat a Chunk as Grace.
  Chunk is the big brute patrolling the East Wing. I used narrow doorways to funnel him, landing shots when he stumbled through. Don’t be afraid to retreat all the way back to a safe room door, poke, and fall back again.
• Internal Dispute – Make a zombie attack another zombie in the hospital wards.
  The easiest setup is the Records Office in the Care Center. Toss a bottle to enrage one zombie so it swings wildly and hits another. Once damage is dealt by one infected to another, the Challenge pops.
• Seasoned Pro – Defeat 300 enemies.
  This is cumulative across the whole game. I got it naturally during my Insanity run, but if you’re short, farm dense encounters in Raccoon City or ARK on Casual.

Collectibles, Safes & Logbook Challenges

• Not Today, Buds! – Defeat all the Plant 43 seedlings.
  There are nine Plant 43 growths around Raccoon City. Just shoot them as you see them. I used a manual save before a big transition and swept each street carefully so I didn’t miss any.
• No Safe is Safe – Open every safe in the main story.
  There are five safes:
  • Bar Lounge safe – Care Center
  • Examination Room safe – Care Center
  • Basement safe – Care Center (contains the Raccoon Roundup Map)
  • Sterilization Chamber safe – ARK
  • Monitor Control Room safe – ARK

  Because there’s no chapter select, always drop a manual save before entering new wings so you can reload if you miss a code.

• Crate Expectations – Open every BSAA container.
  Four BSAA shipping containers are scattered around Raccoon City. They’re large, marked with the BSAA logo. I treated them like mini-safes: cleared the combat space, then scanned corners and alley dead-ends before moving on.
• Case Closed – Read all the files in the main story.
  There are 75 files total. The good news is that file progress carries over between playthroughs, so you don’t have to be perfect on your first run. Make a habit of interacting with every desk, clipboard, and glowing document you see.
• You Little Rascal! – Destroy every Mr. Raccoon memoriam.
  There are 25 total bobbleheads across the game. Once you open the Care Center Basement safe and grab the Raccoon Roundup Map, it becomes much easier to clean these up. I left a manual save before leaving each major area so I could reload if the end-of-area counter showed I’d missed one.

These are the main reason backup saves are so powerful. I strongly recommend a “collectible run” on Casual where you ignore time pressure and just clean up files, Raccoons, safes, and BSAA crates.

Economy & Meta Challenges (Credits, Models, CP Sinks)

• Credit Where Credit is Due – Earn 200,000 Credits.
  You primarily get Credits as Leon via kills tracked by the Tactical Tracker in the Central Camp. I equipped score-boosting charms and replayed dense combat sections until the total ticked over 200k.
• Model Mania – View all models.
  Every character and enemy model must be purchased in the Bonuses menu using CP. This is a “capstone” Challenge—by the time you have enough CP for all models, you’ve likely cleared most other Challenges.
• Curator – View all concept art.
  Same idea as Model Mania but for art galleries. Once I was done unlocking gameplay-affecting extras (weapons, infinite ammo), I dumped CP into art and models to finish these two off.

Between Credits and CP, you’re effectively managing two separate currencies. My rule of thumb:

• Spend Credits freely on survival (ammo, upgrades) to make higher-difficulty Challenges doable.
• Spend CP strategically on unlocks that make Insanity and speedruns easier (infinite ammo, unbreakable melee), then blow the rest on models and art once you’ve cleared the hardest Challenges.

Putting It All Together

If you want an efficient route to 100% Challenges and their related trophies/achievements, this is roughly how my successful plan shook out:

• Run 1 (Casual): Blind-ish story clear, grab as many files, Raccoons, safes, and BSAA containers as you can. Complete most Grace and Leon combat/crafting Challenges, plus It’s Been a Long Night and Hope and Requiem.
• Run 2 (Standard Classic): Focus on clean, careful play to unlock Rookie Agent, Rising Agent, and Resolute Agent, while finishing missing collectibles and Blood Collector tasks.
• Run 3 (NG+ Casual): Speedrun + no-healing + Minimalist (if you’re confident), using your upgraded arsenal. Aim to clear Speed Demon and Never Touch the Stuff here.
• Run 4 (NG+ Insanity): With CP-fueled unlocks like infinite ammo, push through Insanity for Remarkable Agent and mop up any remaining combat counters like Seasoned Pro.

Once those are done, it’s mostly just a matter of finishing off Model Mania, Curator, and experimenting to crack The Final Puzzle. If I could do it without a guide on my first pass, you can absolutely polish the rest off now that you know how each Challenge actually works.