Resident Evil Requiem: All Safe Codes & Locations – Trophy Guide

Why these safes matter (and how long I spent on them)

After spending a full evening combing through Rhodes Hill and the ARK, I realized just how easy it is to miss safes in Resident Evil Requiem – and how painful that is if you care about collectibles and trophies. I missed the basement safe on my first run and had to replay a huge chunk because there’s no chapter select yet. This guide is exactly what I wish I’d had: every safe and locker, their codes, locations, rewards, and the files that reveal the combinations, all in one place.

There’s a bit of confusion online about the total count, so let’s clear that up from real gameplay:

• 5 traditional number-dial safes (all during Grace’s sections)
• 1 three-letter locker-style briefcase in the RPD
• All six together are needed for the “No Safe is Safe” trophy / achievement

This guide assumes you’re on Casual or Standard. On Insanity, Capcom changes the combos, so the pattern is the same but the actual numbers differ – more on that below.

How safes and codes work in Resident Evil Requiem

Every number-dial safe in Requiem works on the classic Resident Evil pattern: you spin the dial left and right to hit specific numbers in order. If you’re used to the older games, this will feel familiar, but I still managed to mess up the directions a couple of times.

• Number safes: Use the left/right input to rotate the dial. The game expects something like Left 10 → Right 80 → Left 30 in that exact order.
• Letter locker: The RPD container isn’t a safe, but a three-letter briefcase. You just dial in letters on three wheels.
• Files show the codes: Every combo is written in a document or note. You can brute force, but it’s a waste of time and you’ll miss file-related achievements.
• One safe’s file is found later: The Rhodes Hill basement safe’s code comes from a Leon attic file after a boss, even though the safe itself is opened by Grace earlier.
• Insanity difficulty: All the dial numbers change on Insanity. The directions (left / right order) stay the same, but don’t rely on these specific numbers for that mode.

From experience: always rotate the dial slowly and watch the direction pop-up the moment you start turning. If the safe doesn’t open, you most likely flipped a direction or overshot a number.

Rhodes Hill – all three safes (codes, files, rewards)

Rhodes Hill is where you’ll see most of your early safes. They’re all optional, but the rewards are strong for the early game, especially the Antique Coins and the Mr. Raccoon map.

1. Bar & Lounge safe (Rhodes Hill Care Center)

Location: First floor of the Rhodes Hill Care Center, in the Bar & Lounge area. The safe sits behind the bar counter. You’ll usually enter this room with a couple of zombies milling around near the middle and the bar itself.

Code (Casual / Standard):
Left 10 → Right 80 → Left 30

Where to find the code: The file “Bar & Lounge Safe Code” is in the Office on the first floor of the west wing. It’s on a desk; you practically bump into it while looting that room. You can still open the safe without reading the note, but you’ll want the file for completion.

Reward:
3 Antique Coins

These Antique Coins are used for upgrades in the Parlor later on (stat boosts, inventory-related perks, etc.). Early in the game, these three coins make a real difference, so skipping this safe just slows your long-term power curve.

Personal tip: Don’t make my mistake of trying to crack this in the middle of the fight. Clear the room first, then duck behind the bar and interact with the safe. You don’t want to be stuck in the dial animation while something grabs you from behind.

2. Examination Room safe (Rhodes Hill)

Location: In the Examination Room of the Care Center’s east wing. It’s in a medical cabinet on the right side of the room, near the grisly body missing its organs.

Code (Casual / Standard):
Right 30 → Left 10 → Right 50

Where to find the code: The combo is written in a document on the first floor of the east wing. Look in the room directly north of the Chief Researcher’s Office – it’s the room where the big deformed enemy (the Chunk) bursts out for the first time. The note with the combination sits on a piece of furniture there.

Reward:
3 Antique Coins

Between this safe and the Bar & Lounge one, you’re already at 6 coins, which is huge for early Parlor investments. From my run, grabbing both before you leave Rhodes Hill gives you a noticeable edge heading into the ARK segments.

Common mistake: Players (me included) often clear the Chunk encounter and run straight onward, forgetting to double back for the note. If you’re doing a file-completion run, make a mental note: first Chunk room = safe code note.

3. Basement Furnace safe (Rhodes Hill)

Location: In the basement level of the Rhodes Hill Care Center. You reach this area via the Furnace room, after inserting a special connector to open a locked door. Once through, you’ll see a zombie pacing between a pallet jack and a desk. The safe is inside the desk office area to the right as you enter.

Code (Casual / Standard):
Right 60 → Left 40 → Right 80

Where to find the code: This is the awkward one. The file isn’t actually found while you’re in the basement as Grace. You only get the written combo later, when you’re playing as Leon in the attic after the Chunk boss fight. After the fight, break open the cabinet on your right with Leon’s axe — inside is the document that lists this safe’s combination.

On my first run, I opened the safe by trial and error and then later found the file with Leon and had that “oh, so that’s how they expected you to do it” moment. For trophy runs, make sure you actually pick up that attic file as well; it counts toward the full file-reading achievement.

Reward:
Handgun Ammo x10 and the Raccoon Roundup Map (Rhodes Hill)

Do not skip this. The Raccoon Roundup Map marks all the Mr. Raccoon statues for the Rhodes Hill area. There’s no chapter select and very limited backtracking, so trying to clean these up blind later is miserable. I tried it once without the map and ended up replaying the chapter anyway.

Pro tip: As soon as you grab the map, open it and plan a quick statue route before leaving the Care Center. It saves you from hunting every corner in a panic later on.

Raccoon City – S.T.A.R.S. Office locker briefcase

This one isn’t a “safe” in the traditional sense, but the game counts it toward the No Safe is Safe trophy. It’s also one of the cooler rewards if you like little build optimizations.

4. RPD S.T.A.R.S. locker briefcase (three-letter code)

Location: In the Raccoon Police Department, inside the S.T.A.R.S. Office locker room. You reach it from Reception by climbing the ladder to the first floor. Inside the S.T.A.R.S. Office, look in the locker area; the briefcase is sitting on a bench.

Code (all difficulties):
R – R – R

You just set all three letter dials to R. This one made me smile once I saw the clue.

Where to find the clue:

• In the S.T.A.R.S. Office, grab the Library Card file.
• Go to the Library upper floor and interact with the book that contains a photograph.
• Flip the photo over to see the inscription: “Rebecca Rookie Remarkable”.

Every word starts with R, and that’s your code: R R R.

Reward:
Power-Shades Charm (a charm upgrade; in some translations it’s referred to with an “Ambition”-style name, but it’s the sunglasses charm).

When equipped at a typewriter or charm loadout screen, this charm gives your bullets extra penetration and a damage boost on the final round in the magazine. It’s a subtle but very satisfying nod to certain S.T.A.R.S. members and makes handguns feel much punchier, especially on tight ammo runs.

Unlocking this locker is mandatory for the safe trophy, so don’t ignore it just because it doesn’t look like a classic combination safe.

ARK – Sterilization Chamber & Control Room safes

The final two safes are in the ARK facility, both during Grace’s sections. They’re easy to spot but dangerous to approach if you don’t clear the area properly.

5. Sterilization Chamber safe (ARK)

Location: In the Sterilization Chamber, on a workbench at the back right corner as you first enter the room. A Licker patrols this area the first time you come through, which is what makes this safe so tense to approach.

Code (Casual / Standard):
Right 10 → Left 90 → Right 20

Where to find the code: The note with this combination is on the lower floor, inside an Umbrella Corporation container at the base of the stairs between the Antechamber and Bio-Weapon Storage 05. It’s hard to miss if you’re looting carefully.

Reward:

• Handgun Ammo x15
• Cocktail Molotov
• Med Injector

In my Insanity-leaning practice runs, that Molotov has saved me from more than one Licker ambush. Opening this safe before pushing deeper into the ARK gives you a nice emergency panic button and a healthy ammo bump.

Survival tip: If you’re low on resources, it’s absolutely viable to sneak this Licker instead of fighting it. Stay crouched, move slowly, and only interact with the safe once the Licker has patrolled away from your corner. Just remember the interaction animation locks you in for a moment, so pick your window carefully.

6. Monitor Control Room safe (ARK)

Location: In the Monitor Control Room (sometimes just called Control Room) off the ARK’s main hall. Walk to the very back of the room; the safe is against the far wall, easily visible next to the bank of monitors.

Code (Casual / Standard):
Left 50 → Right 60 → Left 80

Where to find the code: The file is in Bio-Weapon Storage 05, inside a container in the middle of the room. On the map, it’s the rightmost of the central containers. I walked past it the first time because I was more focused on the enemies than the environment, so sweep this room after you clear it.

Reward:

• Med Injector
• Empty Bottle
• Bottle of Acid

The Empty Bottle and Bottle of Acid are great crafting components for stronger offensive tools later. Getting this safe early in your ARK route lets you lean into acid-based crowd control, which shines against tankier bio-weapons.

Route tip: I like to grab the code from Storage 05 on the way in, clear the nearby threats, then hit the Control Room safe on the way back toward the main hall. It keeps your inventory topped up before the next big set-piece.

Trophies, missables, and Insanity mode notes

To summarize the meta layer, here’s what matters for completion and trophies:

• “No Safe is Safe” trophy: You must open all five number safes plus the RPD locker briefcase in a single playthrough/save file.
• Files / lore trophy: Every safe code is also a file. If you’re chasing the “read every document” style trophy, make sure you actually pick up each code note, even if you already know the combo.
• Missability: With no chapter select and tight backtracking, Rhodes Hill’s basement safe and Mr. Raccoon map are the easiest to miss. The RPD and ARK safes are also locked behind story progression, so don’t rush past them.
• Manual saves: I strongly recommend keeping a manual save at the start or middle of each major area (Rhodes Hill, RPD, ARK). If you realize you forgot a safe, you won’t have to redo the whole game.
• Insanity mode: On Insanity, all numeric codes change. The left/right order I’ve listed stays the same, but the digits are different. For that difficulty, always rely on the in-game documents you find in that run rather than guide numbers.

Once you know where every safe is and how the files connect, opening all six containers in a fresh run only adds maybe 10–15 minutes of extra exploration. Compared to replaying half the game because you missed a single Mr. Raccoon map, that’s a bargain.

Quick reference – all safe and locker codes & rewards

All combos below are for Casual / Standard difficulty:

• Rhodes Hill – Bar & Lounge safe
  Code: Left 10 → Right 80 → Left 30
  Reward: 3 Antique Coins
• Rhodes Hill – Examination Room safe
  Code: Right 30 → Left 10 → Right 50
  Reward: 3 Antique Coins
• Rhodes Hill – Basement Furnace safe
  Code: Right 60 → Left 40 → Right 80
  Reward: Handgun Ammo x10, Raccoon Roundup Map (Rhodes Hill)
• RPD – S.T.A.R.S. locker briefcase
  Code: R – R – R
  Reward: Power-Shades Charm (bullet penetration + final round damage boost)
• ARK – Sterilization Chamber safe
  Code: Right 10 → Left 90 → Right 20
  Reward: Handgun Ammo x15, Cocktail Molotov, Med Injector
• ARK – Monitor Control Room safe
  Code: Left 50 → Right 60 → Left 80
  Reward: Med Injector, Empty Bottle, Bottle of Acid

If you route these into your normal story progression, you’ll grab extra ammo, heals, crafting tools, upgrade currency, and a unique charm — all while knocking out the No Safe is Safe trophy and setting yourself up for faster collectible clean-up runs. If I can keep all six straight after fumbling them on my first attempt, you absolutely can too.